Chronic hemolytic anemia due to novel α-globin chain variants: critical location of the mutation within the gene sequence for a dominant effect

Approximately 30 hemoglobin (Hb) α-chain variants may entail chronic hemolytic anemia (CHA).[1][1],[2][2] In some, interaction between heme and globin is hampered, leading to an unstable Hb. In others, the change affects the domain which binds AHSP and associates with the β-chain partner.[3][3]