TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

We thank Ana Cuadrado for her help with the setting up of ChIP-seq. We thank Tommaso Vicanolo for his help in differentiating cells. We are indebted to Orlando Domi´nguez and the Genomic Unit from CNIO for their advice and for the generation of the libraries. We thank Diego Megi´as from the Confocal Microscopy Unit at CNIO for his help with the quantification of the immunofluorescence and RNA-FISH. We are grateful to Jeannie T Lee and Catherine Hsueh-Ping Chu for kindly sharing the CHIRT protocol and for assistance with details. Research in the Blasco lab is funded by the Span- ish Ministry of Economy and Competitiveness Projects (SAF2013-45111-R and SAF2015-72455-EXP), the Comunidad de Madrid Project (S2017/BMD-3770), the World Cancer Research (WCR) Project (16–1177) and the Fundacio´ n Boti´n (Spain).