Sodium Acetate‐catalyzed Regiospecific and High Stereoselective Aminobromination of β,β‐Dicyanostyrene Derivatives with NBS as Nitrogen/Bromine Source
2012
An easy and efficient method for the aminobromination of β,β-dicyanostyrene derivatives with NBS as the aminobrominating reagent in CH3CN catalyzed by NaOAc (10 mol%) is developed. This protocol provides convenient process to convert β,β-dicyanostyrene derivatives into the vicinal haloamines with full regiospecificity and high stereoselectivety in the ice-water bath in air. The reaction is high efficient in yielding the corresponding aminobrominated products in excellent yields (up to 95%) under these conditions. The outcome indicated that the reaction has an electrophilic addition feature. 12 Eexamples of β,β-dicyanostyrene derivatives have been investigated.
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