Preparation and Properties of Sodium Carboxymethyl Cellulose-Hyaluronic Acid-Carboxymethyl Chitosan Blend Films

The Sodium Carboxymethyl Cellulose (CMC)-Hyaluronic Acid (HA)-Carboxymethyl Chitosan (CMCS) blend films were prepared by solution method, and then characterized by FT-IR,XRD,SEM, water absorption capability, measurement of mechanical properties, degradation characteristic by PBS solution and enzyme.The results suggested that there were strong molecular interaction and good compatibility in the blend films.The chemical degradation and biodegradation experiments proved that the degradation speed was decreased effectively and played the role of the local barrier material in the required time when the content of CMC was 75% (wt%) ,mHA:mCMCS=1.5:1 with cross-linking agent by 0.8% (wt%) 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC).The blend films are expected to be used as controllable degradation biomaterials in the field of postsurgical hemostasis and anti-adhesion.