Synthesis and biological evaluation of type VI β-turn templated RGD peptidomimetics

Abstract We report the design, synthesis, and binding affinities of a family of cyclic RGD peptides attached to type VI β-turn scaffolds. The analogues prepared exhibit interesting binding data to the isolated receptors α v β 3 and α v β 5 . The results demonstrate the utility of these type VI β-turn scaffolds for the constraint of biologically relevant peptides.