A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker.

Lina Luo,Ragu Ramanathan,Lauren Horlbogen,Sumathy Mathialagan,Chester Costales,Manoli Vourvahis,Christopher L. Holliman,A. David Rodrigues

A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker.

2020

Lina Luo
Ragu Ramanathan
Lauren Horlbogen
Sumathy Mathialagan
Chester Costales
Manoli Vourvahis
Christopher L. Holliman
A. David Rodrigues

There is growing interest in using endogenous compounds as drug transporter biomarkers to facilitate drug-drug inter-action (DDI) risk assessment in early Phase I clinical trials. Compared to other...

Keywords:

Carnitine
Chemistry
Biochemistry
Clinical trial
Endogeny
Hydrophilic interaction chromatography
Transporter
early phase
Chromatography
Organic cation transport proteins
Biomarker (medicine)

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