A kind of synthetic method for the BTK inhibitor Acalabrutinib for treating chronic lymphocytic leukemia

A kind of synthetic method for the BTK inhibitor Acalabrutinib for treating chronic lymphocytic leukemia, step：Prepare (S) 2 (8 aminooimidazoles simultaneously the base of [1,5 a] pyrazine 3) 1 pyrrolidinecarboxylic acid benzyl ester；Prepare (S) 2 (base of 8 t-butoxycarbonyl amino imidazos [1,5 a] pyrazine 3) 1 pyrrolidinecarboxylic acid benzyl ester；Prepare (S) 2 (base of the bromine imidazo of 8 t-butoxycarbonyl amino 1 [1,5 a] pyrazine 3) 1 pyrrolidinecarboxylic acid benzyl ester；Prepare (S) 2 { base of 8 t-butoxycarbonyl amino 1 [4 (2 pyridine radicals carbamyl) phenyl] imidazo [1,5 a] pyrazine 3 } 1 pyrrolidinecarboxylic acid benzyl ester；Prepare (S) 2 { base of 8 t-butoxycarbonyl amino 1 [4 (2 pyridine radicals carbamyl) phenyl] imidazo [1,5 a] pyrazine 3 } pyrrolidines；Prepare (S) 2 { base of 8 t-butoxycarbonyl amino 1 [4 (2 pyridine radicals carbamyl) phenyl] imidazo [1,5 a] pyrazine 3 } 1 (2 butine acyl group) pyrrolidines；Prepare Acalabrutinib.High income；Simple flow；It is green.