Mobile phase selection for high-performance liquid chromatographic analysis of novel zinc(II) carboxylates with N-donor ligands

Abstract The PRISMA optimization project was used for mobile phase selection in the HPLC analysis of novel zinc(II) carboxylates of the type Zn(RCOO) 2 · L n · q (H 2 O) with N-donor ligands. The composition of the mobile phase is characterized by the solvent strength ( S T ) and the selection points ( P S ). At a constant S T the correlation between P S and retention data can be described by a quadratic function. For constant P S the solvent strength and retention data correlate with a logarithmic function. On the basis of the results obtained in the TLC separation of the single zinc(II) carboxylate, solvents were chosen (ethanol, acetonitrile, methanol, dioxane, 2-propanol) that are suitable for HPLC analyses of zinc(II) carboxylates on LiChrosorb RP-8 and RP-18 columns.