PO103 Impulse control disorders in familial parkinson’s disease

Objective To characterise impulse control problems in familial PD, and explore genetic associations Background Impulse control disorders are pathological behaviours that include hypersexuality, compulsive gambling, shopping and eating. Methods Participants were recruited through the BNSU as part of the Parkinson’s Families Project. Demographic and clinical data were collected using validated scales, including the QUIP-S. Whole Exam Sequencing was completed for 31 participants and we undertook a candidate SNP analysis. ICD status was assigned using either ≥1 or 2 positive answers to the ICD behaviours in the QUIP Results There were 145 participants with ≥1 1 st or 2nd degree relative with PD. Using the published criteria of the QUIP-S 33% had ≥1 ICD (compulsive buying 16.8%, hypersexuality 13.3%, compulsive eating 12.8%, pathological gambling 7.9%). This contrasted to a 10.8% overall prevalence when both questions to each behaviour were positive (hyper sexuality 6.9%, compulsive buying 3.0%, pathological gambling 2.5%, compulsive eating 0%). None of the published clinical risk factors were statistically different in the ICD +vs ICD- groups. One SNP (rs1806201) in GRIN2B showed a significant association with ICD status using 2 positive answers on the QUIP. This didn’t survive Bonferroni correction Conclusion Using the two-response cutoff for the QUIP-S significantly changes the the positive rate of the QUIP-S, which may increase the PPV, potentially at the expense of reducing the NPV. We continue to work on genetic associations with ICD in PD.