Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: in vitro, ex vivo and in vivo investigation.

Faezeh Sharifi,Mansour Jahangiri,Pedram Ebrahimnejad

Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: in vitro, ex vivo and in vivo investigation.

2021

Faezeh Sharifi
Mansour Jahangiri
Pedram Ebrahimnejad

The goal of the current study was to target 7-ethyl-10-hydroxycamptothecin (SN38) orally to colon tumours by synthesizing a targeting polymer. To achieve the optimum delivery for SN38, initially me...

Keywords:

Nuclear chemistry
Chemistry
Polymer
Chitosan
In vitro
Polyethylene glycol
Nanoparticle
Hyaluronic acid
In vivo
Ex vivo

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