Synthesis of 3-diethylphosphonoyl-2-hydroxy-prop-2-ylphosphonate and -phosphine oxide derivatives via the Pudovik reaction of diethyl 2-oxopropylphosphonate on the surface of Al2O3/KF

Abstract A series of dialkyl 3-diethylphosphonoyl-2-hydroxy-prop-2-ylphosphonates and a diphenylphosphine oxide, new representatives within the large family of α–hydroxyphosphonates, were prepared via the Pudovik reaction of the corresponding dialkyl phosphites or diphenylphosphine oxide with diethyl 2–oxopropylphosphonate on the surface of Al2O3/KF. The conformation of the α–hydroxy-ethylenebisphosphonate derivatives was established on the basis of stereospecific 3J(PC) constants.