Purification and Properties of Mammalian 5’-Methylthioadenosine Phosphorylase and Bacterial 5’-Methylthioadenosine Nucleosidase: Pharmacological Implications and Perspectives

A successful approach to antibacterial therapy is generally based on enzymatic and metabolic differences between eukaryotes and prokaryotes. Indeed comparative studies have yielded, so far, a rich harvest of clinically efficacious antibacterial drugs characterized by low toxiCity.