Apixaban linearity profile for hydrotropic solubilization

A study on the hydrotropic solubility and linearity profile of Apixaban was carried out by using Sodium Salicylate as the solubilizing agent as Apixaban is poorly soluble in water. Apixaban was freely soluble in water when 1.5M Sodium Salicylate used as a solubilizing agent. Apixaban shows an absorption maximum at 318nm in the first derivative mode of measurement using UV-Visible spectrophotometer. Pazopanib shows a linear response in the concentration range of 2 microgram/ml to 15 microgram/ml. The outcomes of present semi validated work is useful for the aqueous solubilization and quantitative determination of Apixaban in bulk drug and in pharmaceutical formulations avoiding toxic solvents i.e. green and eco-friendly way.