Spectral domain-optical coherence tomography analysis of choroid osteoma

Objective To observe the image characteristics of eyes with choroidal osteoma using enhanced spectral domain optical Cirrus coherence tomography (SD-OCT),and to explore their relationship with visual acuity.Methods The records and SD-OCT images of 14 patients (18 eyes) diagnosed with choroidal osteoma at this hospital were reviewed retrospectively.All patients received examinations of best corrected visual acuity (BCVA),direct or indirect ophthalmoscope,slit lamp ophthalmoscope,fundus fluorescein angiography,B scan and/or computerized tomography.Subtle structure changes of the retina and choroidal osteoma were observed by four lines of the horizontal,the vertical scanning lines through the foveal and the tumor basal diameter under the model of five Line Raster.The correlation between the retinal and choroidal morphology and visual acuity was evaluated.Results The choroidal features of SD-OCT image of choroidal osteoma can be categorized into hyper-reflective in six eyes (33.3 ％),isoreflective in five eyes (27.8％),hypo-reflective in three eyes (16.7％) and mixing-reflective in four eyes (22.2％).The foveal thickness ranged from 50.2 to 245.1 μm,and the average foveal thickness was (130.2±58.3) μm.The horizontal and vertical diameters of choroidal osteoma ranged from 5.6 to 15.8 mm and 4.6 to 12.8 mm respectively.The average horizontal and vertical diameters of choroidal osteoma were (7.8 ± 2.9) mm and (6.5 ±2.5) mm respectively.The statistical analysis revealed that BCVA was not related to the horizontal,vertical diameters of choroidal osteoma or the foveal thickness (r =0.262,0.229,0.137; P =0.284,0.294,0.362).BCVA was related to the involvement of fovea and the integrity of photoreceptor inner/ outer segment junction (IS/OS) (r=-3.838,-4.559; P=0.001 5,0.000 3),but not related to macular choroidal neovascularization (CNV) or serous retinal detachment (r=-0.144,0.411; P=0.684,0.687).Conclusions The main SD-OCT image characteristics of eyes with choroidal osteoma was hyper-reflective and isoreflective.BCVA was not related to the horizontal,the vertical diameters of choroidal osteoma,the foveal thickness,macular CNV or serous retinal detachment.It was related to the involvement of fovea and the integrity of IS/OS. Key words: Choroid neoplasms/diagnosis;  Tomography, optical coherence