Electrical Stimulation of Human Mesenchymal Stem Cells on Conductive Nanofibers Enhances their Differentiation toward Osteogenic Outcomes

Tissue scaffolds allowing the behaviour of the cells that reside within them to be controlled are of particular interest for tissue engineering. Herein we describe the preparation of conductive fiber-based bone tissue scaffolds (nonwoven mats of electrospun polycaprolactone with an interpenetrating network of polypyrrole and polystyrenesulfonate) that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation towards osteogenic outcomes.