ETHANOL EXTRACT OF TIKEN LEAVES (Fraxinus griffithii Clarke) AS ANTICONVULSANT IN MICE

Tiken plants (Fraxinus griffithii Clarke) has been used as traditional medicine in Indonesia or other countries. Research has demonstrated that tiken bark extract may prolong barbiturate sleeping time and also have anticonvulsant effects in mice. This research was carried out using ethanol extract of tiken leaves to study its anticonvulsant effect in mice. The study used five groups of experimental animals. The groups consisted of one control group, three treatment groups, and one standard group. The control group was given CMC Na suspension, treatment groups were given ethanol extract of tiken leaves at doses of 4000,5000 and 6000 mg/kg body weight, respectively, the standard group was given Phenobarbital sodium solution at dose of 26 mg/kg body weight. Sixty minutes after treatment, all mice were induced using electroshock induced seizures. Anticonvulsant effect was determined by reduction in seizure duration. There were statistically significant differences in seizure duration between treatment, standard, and control groups. It can be concluded that the ethanol extract of tiken - leaves have anticonvulsant effect in mice.