DPN writing on non-flat gold surfaces and detection by SERS
2009
There is a need for fast, reliable and sensitive biosensor arrays. We have used nanostructured plasmonic gold surfaces for
the detection of biological species by surface enhanced resonance Raman scattering (SERRS). Careful, directed
placement by Dip-Pen Nanolithography (DPN) of the biological species or capture chemistry, within the array facilitates
efficient read out via fast Raman line mapping. In addition, we can apply parallel deposition methods to enhance the
throughput of these combined techniques. SERRS is an extremely sensitive spectroscopic technique that offers several
advantages over conventional fluorescence detection. For example, the high sensitivity of the method allows detection of
DNA capture from single plasmonic array "pixels" ~1 μm 2 in area. Additionally, the information rich nature of the
SERRS spectrum allows multiple levels of detection to be embedded into each pixel, further increasing the information
depth of the array. By moving from micro- to nano-scale features, sensor chips can contain up to 105 times more
information, dramatically increasing the capacity for disease screening.
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