Neuropathic Pain: Mirna-547-5p-Mediated IL-33/ST2 Signaling and Bone Marrow Stromal Cell Therapy
2021
We have recently identified that the depression of MicroRNA (miRNA)-547-5p, which can be induced by a Chronic
Constriction Nerve Injury (CCI), is an upstream event causing the enhancement of interleukin-33 (IL-33)/
Suppressor Tumorigenicity 2 (ST2) signaling and leading to pain hypersensitivity in rats. Moreover, the application of
Bone Marrow Stromal Cells (BMSCs) reduces CCI-induced pain hypersensitivity by blocking the depression of
miRNA-547-5p or its downstream molecules IL-33 and ST2. The roles of the miRNA-547-5p/IL-33/ST2 signaling
pathway in the genesis of neuropathic pain and the analgesic effects of treatment with BMSCs are further discussed
in this mini-review.
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