Differential Stem and Progenitor Cell Trafficking by Prostaglandin E2

Jonathan Hoggatt,Khalid S. Mohammad,Pratibha Singh,Amber F. Hoggatt,Brahmananda R. Chitteti,Jennifer M. Speth,Peirong Hu,Bradley Poteat,Kayla N. Stilger,Francesca Ferraro,Lev Silberstein,Frankie Wong,Sherif Farag,Magdalena Czader,Ginger L. Milne,Richard M. Breyer,Carlos H. Serezani,David T. Scadden,Theresa A. Guise,Edward F. Srour,Louis M. Pelus

Differential Stem and Progenitor Cell Trafficking by Prostaglandin E2

2013

Endogenous prostaglandin E2 (PGE2) is a potent regulator of haematopoietic stem cell (HSC) retention in the bone marrow; inhibition of endogenous PGE2 signalling by non-steroidal anti-inflammatory drugs results in enhanced HSC and haematopoietic progenitor cell mobility via E-prostanoid 4 (EP4) receptor antagonism.

Keywords:

Prostaglandin E2
Progenitor cell
Bone marrow
Stem cell
Prostaglandin
Haematopoiesis
Hematopoietic Stem Cell Mobilization
Cell biology
Receptor
Biology
Transplantation
Progenitor
Prostaglandin E2 receptor

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