Dietary Pterostilbene and Resveratrol Modulate the Gut Microbiota Influenced by Circadian Rhythm Dysregulation

SCOPE A causal relationship between circadian misalignment and microbiota dysbiosis has been discussed recently, due to their association to pathogenesis. Herein, the possible impact of pterostilbene and resveratrol on the gut microbiota brought by chronic jet-lag in mice was investigated. METHODS AND RESULTS Dietary supplement of resveratrol and pterostilbene (0.25%) were given to 16-week-jetlagged mice to examine the effects on microbiota and physiological functions. Jetlag significantly induced weight gained that could be effectively prevented by pterostilbene. Both supplements also retained oscillation patterns that found to be lost in JLG group, including serum biochemical parameters and gut microbiota. The results of beta diversity suggested the supplementations efficiently led to distinct gut microbial composition as compared to JLG group. Besides, the supplementation forestalled some microbial elevation, such as Eubacterium ventriosum and Acetitomaculum. Growth of health beneficial bacteria like Blautia and Lachnospiraceae UCG-001 was facilitated and abundance of these bacteria could be correlated to oscillation of biochemical parameters. Result of KEGG indicated distinct effect brought by microbial re-shaping. CONCLUSION Our result suggested that supplementation of resveratrol and pterostilbene could potentially dampen some adverse effects of gut microbiota dysbiosis, and at the same time, re-composite and facilitate the growth of health beneficial microbiota. This article is protected by copyright. All rights reserved.