Difference fourier transform infrared evidence for ester bound linking the heme group in myeloperoxidase, lactoperoxidase, and eosinophil peroxidase

E. C. Slater Institute, BioCentrumUniVersity of Amsterdam, Plantage Muidergracht 121018 TV Amsterdam, The NetherlandsApplied Genetics, UniVersity of BrusselsRue de l’Industrie 24, B-1400 NiVelles, BelgiumReceiVed July 28, 1997The homologous mammalian peroxidase family comprisesmyeloperoxidase (MPO), lactoperoxidase (LPO), eosinophilperoxidase (EPO), and thyroid peroxidase (TPO). MPO sharesrespectively 61, 70, and 47% identical residues with theseperoxidases,