Changes in antioxidant enzymes activities, aggregability and malonyldialdehyde concentration in blood platelets from patients with coronary heart disease

Abstract In 41 patients with coronary heart disease (CHD) the concentrations of total blood platelet malonyldialdehyde (MDA: 2.11 ± 0.25 nmol/10 9 platelets) and MDA corresponding to thromboxane A 2 (TXA 2 0.84 ± 0.13 nmol/10 9 platelets) were increased in comparison with values in blood platelets of healthy subjects (1.19 ± 0.09 and 0.71 ± 0.05 nmol/10 9 platelets), respectively. The increased aggregability with ADP and thrombin of patient platelets was also observed. In relation to the blood platelets of healthy subjects, the antioxidant enzymes activities of patient blood platelets were significantly ( P