Safety of parecoxib when used for more than 3 days for the management of postoperative pain

Aim: To assess parecoxib safety when used for >3 days for postoperative pain management. Methods: Treatment-emergent adverse event (TEAE) occurrence after day 3 was examined in a pooled analysis of three placebo-controlled trials of parecoxib following general or gynecologic surgery, or total hip arthroplasty. A total of 358 patients received parecoxib, and 318 placebo. Results: Mean treatment duration was similar between treatment groups. The overall frequency of all TEAEs after day 3 was also similar between treatment groups. Most TEAEs occurred in 3 days was low and similar to placebo after treatment day 3.