Polymorphonuclear leukocyte infiltration into the subretinal choroid and optic nerve in response to leukotrienes.

Purpose. To describe the pattern of leukocyte infiltration in ocular anterior and posterior segment tissues in response to local administration of LTB 4 and LTD 4 . Methods. Leukocyte infiltration after intravitreal administration of LTB 4 or LTD 4 was assessed in ocular sagittal cross-sections and compared with vehicle-treated control eyes. Results. A dose-dependent eosinophil infiltration was observed in the subretinal choroid and the ora serrata region of the ciliary body in response to both LTB 4 and LTD 4 , but only LTB 4 behaved as a chemoattractant for neutrophils