Gene Regulation: A Eukaryotic Perspective

Part 1 Tissue-specific expression of proteins and messenger RNAs: tissue-specific expression of proteins and of messenger RNAs. Part 2 the DNA of different cell types is similar in both amount and type: DNA loss DNA amplification DNA rearrangement. Part 3 Regulation at transcription: levels of gene regulation evidence for transcriptional regulation regulation at transcriptional elongation. Part 4 Post-transcriptional regulation: regulation after transcription? regulation of RNA splicing regulation of RNA transport and of RNA stability regulation of translation. Part 5 Transcriptional control - chromatin structure: commitment to the differentiated state and its stability chromatin structure changes in chromatin structure in active or potentially active genes other changes in DNA and its associated proteins in active or potentially active genes DNaseI hypersensitive sites in active or potentially active genes. Part 6 Transcriptional control - DNA sequence elements short sequence elements located within or adjacent to the gene promoter enhancers role of repeated sequences regulation of transcription by RNA polymerases I and III. Part 7 Transcriptional control - transcription factors: DNA binding by transcription factors activation of transcription what activates the activators? Part 8 Gene regulation and cancer: proto-oncogenes elevated expression of oncogenes transcription factors as oncogenes. Part 9 Conclusions and future prospects.