Immunological and allergological aspects of macrolides application in clinic

The review analyzes clinical significance of immunotropic properties of macrolides. Macrolides have effect of phagocytic activity and cell motility, inhibit production of proinflammatory cytokines, increase antimicrobial function of mucosa epithelium. They significantly decrease the intensity of inflammatory reactions in local and systemic infectious processes, especially in respiratory tract pathology including that of allergic genesis. Efficacy of macrolides in bronchial asthma is extended by suppressing eosinophil functioning, antispastic effect of these preparations over smooth muscles and decreasing of mucus formation in bronchi.