Synthesis of Fully Protected Nucleoside- Folic Acid Conjugated Phosphoramidites and Their Incorporation into Antisense Oligonuleotides
1999
Abstract A novel synthesis of the nucleoside-folic acid conjugates has been accomplished. This approach allowed us to synthesize several analogs, which were converted to phosphoramidites and successfully incorporated into therapeutically active antisense oligonucleotides.
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