Non-central diabetic clinical significant macular edema treatment with 532nm sub threshold laser

Purpose: is to determine if Sub Threshold Laser at 532 nm can reduce macular thickness in non-central Clinical Significant Macular Edema (CSME) and stop the progression of non-central CSME to central CSME. Methods: 8 eyes in 6 patients were diagnosed with non-central CSME using OCT and were treated with Sub Threshold Laser at 532 nm using 5 % duty cycle using high density low intensity application on the area of the edema, retreatment was allowed with Sub Threshold Laser whenever macular edema worsening. Main outcome and measures: A complete fundus exam including best-corrected visual acuity changes within 24 weeks, improvement of non-central retinal thickness and monitoring glycemic control. Results: Reduction of retinal thickness from 384.5±64.5µm to 311.33±51.7µm at 24 weeks follow up (P<0.05) without changes of best corrected visual acuity along with reduced risk of progression to central CSME and visual loss with no sign of laser burns at the macular area. Conclusion: 532nm subthreshold laser is effective in NON-central CSME treatment for 24 weeks follow up and reduce the risk of visual loss due development of central CSME without causing retinal scars.