Visual development of postoperative persistent macular holes with and without surgical revision

BACKGROUND: Postoperative persistent macular holes after vitrectomy are a rare, but typical phenomenon. Without further surgical intervention the visual acuity remains unchanged. There are no generally accepted treatment recommendations for these cases. We report on 23 cases with postoperative persistent macular holes with and without further surgical treatment and analyzed the clinical outcome. METHODS: A retrospective case control study was performed and visual acuity and anatomic status of the macular holes were analysed in 23 cases with a persistent macular hole after previous vitrectomy. Seven patients refused further surgical treatment (group 1) and were used as a control group. Three patients received a second intravitreal gas tamponade without further surgical manipulation (group 2). A vitrectomy revision with endotamponade was performed in 13 eyes (group 3). Additional autologous blood on the macular hole was used in 4 cases and adjuvant ICG-assisted peeling of the inner limiting membrane around the macular hole was performed in another 9 cases. RESULTS: The eyes of group 1 showed a statistically not significant (p = 0.56) change of the median LogMAR visual acuity from 1.3 (range 0.7 - 1.4) to 1.2 (range 0.3 - 2.0) over a median follow-up of 11.8 months. No eye in group 2 developed a closure of the macular hole. After a median follow-up of 3.6 months the LogMAR visual acuity dropped statistically not significantly from 0.7 (range 0.7 - 1.9 to 1.0 (range 0.8 - 1.0; p = 0.5). 61 % of eyes showed a closure of the macular hole after a second vitrectomy (group 3). Eight out of 16 retreated eyes had finally a persistent macular hole. In these cases median LogMAR visual acuity decreased insignificantly from 1.0 (range 0.7 - 1.4) to 1.1 (range 0.7 - 1.4; p = 0.27) during a median follow-up of 13.7 months. In 8 eyes with a finally closed macular hole median LogMAR visual acuity increased statistically significantly from 0.8 (rage 0.4 - 1.3) to 0.35 (range 0.04 - 0.9; p = 0.016) after a median follow-up of 8.1 months. CONCLUSION: Surgical revision of postoperative persistent macular holes using vitrectomy and endotamponade showed a success rate of 61 %. Eyes that had unsuccessful subsequent surgery had a slight decay of the visual acuity during the follow-up that was similar to that of eyes without further surgical treatment. In contrast, the final closure of the macular hole after a second surgery was associated with a significantly increased visual acuity.