Direct Single Gene Mutational Events Account for Radiation-Induced Intestinal Adenoma Yields in ApcMin/+ Mice

Abstract Ellender, M., Harrison, J. D., Edwards, A. A., Bouffler, S. D. and Cox, R. Direct Single Gene Mutational Events Account for Radiation-Induced Intestinal Adenoma Yields in ApcMin/+ Mice. Radiat. Res. 163, 552–556 (2005). Data on the induction of small intestinal tumors, predominantly adenomas, by X radiation in ApcMin/+ mice are reported. Comparison of these incidences with estimates of radiation-induced direct single gene mutation frequencies taken from the literature support the hypothesis that direct mutational loss of Apc+ is the sole requirement for initiation of adenoma. Furthermore, estimates of radiation-induced initiation of adenoma per target stem cell in this animal model are similar to or less than radiation-induced direct somatic gene mutation frequencies. Therefore, while the data reported here do not preclude a role for genomic instability in tumor progression, it is not necessary in this model to postulate the involvement of radiation-induced transmissible genomic instability in in...