UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

Michelle Yi-Xiu Lim,Gregory G. LaMonte,Marcus C. S. Lee,Christin Reimer,Bee Huat Tan,Victoria V. Corey,Bianca F Bf Tjahjadi,Adeline Chua,Marie Nachon,René Wintjens,Peter Gedeck,Benoit Malleret,Laurent Rénia,Ghislain M.C. Bonamy,Paul C. Ho,Bryan K. S. Yeung,Eric D. Chow,Liting L. Lim,David A. Fidock,Thierry T. Diagana,Elizabeth A. Winzeler,Pablo Bifani

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

2016

Mutations in two previously unreported Plasmodium falciparum genes, acetyl-CoA transporter (pfact) and UDP-galactose transporter (pfugt), convey resistance to two imidazolopiperazine antimalarial compounds.

Keywords:

Gene
Acetyl-CoA
Biochemistry
Multiple drug resistance
UDP galactose
Transporter
Bioinformatics
Medicine
Plasmodium falciparum
Genetics
Plasmodium berghei
CRISPR
Drug resistance
Mutant

Correction
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