Plasma levels and dialysance of atrial natriuretic peptide in terminal renal failure

Plasma levels and dialysance of atrial natriuretic peptide in terminal renal failure. Plasma immunoreactive atrial natriuretic peptide (irANP) levels, their chromatographic profile, relationship with hemodynamic variables, and responses to hemodialysis (HD) or postural changes were investigated in HD patients. Peripheral venous supine plasma irANP averaged 167 ± 31 (±SEM) pg/ml in 12 normal subjects (age 63 ± 2 yr). In 42 HD patients (mean age 63 ± 1 yr), plasma irANP in peripheral arterio-venous fistulae was high (447 ± 50 pg/ml, P