TOPOGRAPHIC CHANGES IN MACULAR GANGLION CELL-INNER PLEXIFORM LAYER THICKNESS AFTER VITRECTOMY WITH INDOCYANINE GREEN-GUIDED INTERNAL LIMITING MEMBRANE PEELING FOR IDIOPATHIC MACULAR HOLE.

To evaluate the topographic changes in macular ganglion cell-inner plexiform layer (GCIPL) thickness after vitrectomy with indocyanine green-guided internal limiting membrane (ILM) peeling in eyes with idiopathic macular hole.This is a retrospective analysis of 58 consecutive eyes with surgically closed macular hole after vitrectomy with indocyanine green-guided ILM peeling. Further, 31 eyes that had undergone vitrectomy without ILM peeling were used as the control group. The macular GCIPL thickness was measured with spectral domain optical coherence tomography before vitrectomy and at 1 month and 6 months after vitrectomy.The preoperative mean GCIPL thickness was 78.79 μm and mean thickness at 1 month and 6 months after surgery significantly reduced progressively to 70.93 μm and 67.64 μm (P < 0.001 and P < 0.001, respectively). The postoperative mean GCIPL thickness was significantly lower than that of the group without ILM peeling at 1 month and 6 months postoperatively (P < 0.001, P < 0.001, respectively). The GCIPL thickness in the temporal area was significantly lower than in the nasal area at 1 month and 6 months postoperatively (P < 0.001, P < 0.001, respectively).A reduction of the macular GCIPL thickness was observed after vitrectomy with indocyanine green-guided ILM peeling for idiopathic macular hole, especially in the temporal area.