The Pattern and Magnitude of “InVivo Thrombin Generation” Differ in Women with Preeclampsia and in Those with SGA Fetuses without Preeclampsia

AbstractObjective: We aimed to determine the differences in the pattern and magnitude of thrombin generation between patients with preeclampsia (PE) and those with SGA.Methods: This cross-sectional study included women in the following groups: 1) normal pregnancy (NP) (n = 49); 2) PE (n = 56); and 3) SGA (n = 28). Maternal plasma thrombin generation (TGA) was measured, calculating: a) lag time (LT); b) velocity index (VI); c) peak thrombin concentration (PTC); d) time-to-peak thrombin concentration (TPTC); and e) endogenous thrombin potential (ETP).Results: 1) The median TPTC, VI, and ETP differed among the groups (p = 0.001, p = 0.006, p < 0.0001); 2) the median ETP was higher in the PE than in the NP (p < 0.0001) and SGA (p = 0.01) groups; 3) patients with SGA had a shorter median TPTC and a higher median VI than the NP (p = 0.001, p = 0.006) and PE (p < 0.001, p = 0.003) groups.Conclusions: 1) Patients with PE have higher in vivo thrombin generation than women with NP and those with an SGA fetus; 2) th...