Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells: acceleration of cAMP generation and inhibition of phosphodiesterase

H. Makino,Taketoshi Saijo,Yasuko Ashida,Hisashi Kuriki,Yoshitaka Maki

Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells: acceleration of cAMP generation and inhibition of phosphodiesterase

1987

H. Makino
Taketoshi Saijo
Yasuko Ashida
Hisashi Kuriki
Yoshitaka Maki

Amlexanox markedly inhibits histamine release from rat mast cells. To clarify the mechanism of this inhibition, we investigated the effect of amlexanox on cAMP content, which, when increased, inhibits

Keywords:

Peritoneum
Amlexanox
Histamine
Immunology
Mechanism of action
Antiallergic agent
Endocrinology
Biology
Mast cell
Phosphodiesterase
Internal medicine
Tachyphylaxis
IBMX

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