Synthesis of Water-Soluble Quaternized Chitosans and Their Antitumor Activity

water-soluble low-molecular-weight chitosan(LCTS) was prepared by hydrogen peroxide oxidation method and their quaternized derivatives(QLCTS) was also synthesized using previous methods. Their antitumor activity was studied, and the results showed that the LMW and its quaternized derivatives inhibited the growth of pancreatic carcinoma cell strain PANC-1 in vitro, and the inhibitory rate reached 59.2%.