Aminopeptidase A, Generating One of the Main Effector Peptides of the Brain Renin-Angiotensin System, Angiotensin III, Plays a Key Role in Central Control of Blood Pressure

These new tools were used to show that APA and APN are involved in vivo in the metabolism of brain AngII and AngIII, respectively. Then, by blocking each of their metabolic pathways, we determined the respective roles of AngII and AngIII in the central control of arterial blood pressure (BP).