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Xavier Iturrioz

Collège de France
French Institute of Health and Medical Research

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A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia.

2021 Nature Communications
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Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators.

2021
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Structural insight into the catalytic mechanism and inhibitor binding of aminopeptidase A.

2020 Biochemical Journal
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Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents

2019 European Journal of Medicinal Chemistry
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A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor

2017 ChemMedChem
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Synthetic Modification within the “RPRL” Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation

2017 Journal of Medicinal Chemistry
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Analogues peptidiques métaboliquement stables

2017
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Involvement of arginine 878 together with Ca2+ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues.

2017 PLOS ONE
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Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders

2017 Frontiers in Endocrinology
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Corrigendum: Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes

2016 Nature Communications
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