Intravenous Autologous Bone Marrow Mononuclear Cell Transplantation for Stroke Patients

Therapeutic angiogenesis mediated by hematopoietic stem cell transplantation has been initiated in patients with ischemic diseases and has shown promising results. We previously demonstrated that therapeutic angiogenesis is essential for neurogenesis after stroke and that intravenous administration of hematopoietic stem cells improves functional recovery through enhanced angiogenesis in an experimental stroke model. Based on these observations, we initiated a clinical trial of cell therapies with the aim of achieving functional recovery in patients with cerebral ischemia through regenerative microcirculation in the brain following a stroke.