Tumor-associated Tissue and Blood Eosinophils in Oral Squamous Cell Carcinoma

Methods: In the present study, forty-three patients with a diagnosis of oral Squamous Cell Carcinoma (SCC) were evaluated. TATE was determined in ten random fields under ×40 magnification. Laboratory tests of the patients were also evaluated before surgery and repeated at three, six and twelve weeks after surgery. Data were analyzed by descriptive statistical methods (mean ± standard deviation), N (%) , repeated measures ANOVA, Pearson’s correlation coefficient and chi-square test. Statistical significance was defined at p<0.05. Results: There was a correlation between TATE and tumor grade (p=0.03), but there wasn’t any correlation between TATE and tumor size or lymph node involvement. In the analysis of tumor-associated blood eosinophil counts, a correlation was observed with lymph node involvement (p= 0.02), but no correlation was noted with the tumor grade or size. In addition, peripheral blood analysis revealed that blood eosinophilia grades were significantly different one day before surgery from 6 and 12 weeks after surgery. Conclusion: TATE was found to be associated with tumor grade , but not with tumor size or lymph node involvement. A correlation was observed with lymph node involvement, but no correlation was noted with the tumor grade or size. In addition, blood eosinophilia grades were significantly different one day before surgery from 6 and 12 weeks after surgery.