RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

Juan Lin,Snehlata Kumari,Chun Kim,Trieu-My Van,Laurens Wachsmuth,Apostolos Polykratis,Manolis Pasparakis

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

2016

Juan Lin
Snehlata Kumari
Chun Kim
Trieu-My Van
Laurens Wachsmuth
Apostolos Polykratis
Manolis Pasparakis

The enzyme RIPK1 functions through its RHIM domain to prevent ZBP1-mediated activation of RIPK3–MLKL-dependent necroptosis, thus preventing perinatal lethality and skin inflammation in adult mice.

Keywords:

Enzyme
Inflammation
Necroptosis
Perinatal lethality
Immunology
Cancer research
Biology
RIPK1
ZBP1
Protein kinase A
kinase activity
Programmed cell death
Cell biology
Keratinocyte

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