Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy
2017
Preterm birth (PTB) presents a serious medical heath concern in both economically developed
and developing nations, with incidence rate from 15%-11% respectively. Changes in cervical
collagen bundle orientation and distribution may prove to be a predictor of PTB. Polarization
imaging is an effective means to measure optical anisotropy in birefringent biological tissue such
as those rich in collagen. Non-invasive, full-field Mueller Matrix polarimetry (MMP) imaging
methodologies, optical coherence tomography (OCT), and second harmonic generation (SHG)
microscopy were used to assess cervical collagen content and structure in non-pregnant cervices.
In vivo studies using a Mueller Matrix colposcope are underway. Further studies of cervical
collagen orientation throughout pregnancy are needed to understand if Mueller matrix
polarimetry can effectively identify at-risk conditions for PTB.
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