A MASS IMAGING TECHNIQUE REVEALED A RENO-PROTECTIVE EFFECT OF THE XANTHINE OXIDASE INHIBITOR FEBUXOSTAT IN THE ISCHEMIC KIDNEY BY PROMOTING ATP RECOVERY IN THE CORTEX

Kazutoshi Miyashita,Kentaro Fujii,Akiko Kubo,Masaaki Sato,Aika Hagiwara,Hiroyuki Inoue,Masaki Ryuzaki,Sho Endo,Asuka Uto,Makoto Suematsu,Hiroshi Itoh

A MASS IMAGING TECHNIQUE REVEALED A RENO-PROTECTIVE EFFECT OF THE XANTHINE OXIDASE INHIBITOR FEBUXOSTAT IN THE ISCHEMIC KIDNEY BY PROMOTING ATP RECOVERY IN THE CORTEX

2018

Kazutoshi Miyashita
Kentaro Fujii
Akiko Kubo
Masaaki Sato
Aika Hagiwara
Hiroyuki Inoue
Masaki Ryuzaki
Sho Endo
Asuka Uto
Makoto Suematsu
Hiroshi Itoh

Objective:The kidney has different energy metabolism depending on the region. However, the distribution of phosphorylated adenosine (ATP, ADP and AMP) and their alteration after transient ischemia have not been known due to the technical difficulties.Design and method:Imaging mass spectrometry (IMS)

Keywords:

Endocrinology
Diabetes mellitus
Metabolism
Mass spectrometry imaging
Xanthine oxidase inhibitor
Adenosine
Medicine
Phosphorylation
Internal medicine
Febuxostat
Kidney
Cortex (botany)

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