Dating thrombus organization with eosinophil counts in deep venous thrombosis.

OBJECTIVE It's known that eosinophils are essential for thrombus formation. Studies have demonstrated the association of eosinophils with coronary artery disease, stent thrombosis, coronary collateral development, and vasospastic angina. However, there is little data about the association of hemogram parameters, especially eosinophil counts, with deep venous thrombosis (DVT) subgroups. METHODS The present study comprised 243 patients diagnosed with DVT (of whom 86 were acute, 72 were indeterminate, and 85 were chronic) and 75 control subjects. Medical records of all the patients were reviewed, and relevant data were collected retrospectively. The baseline characteristics, as well as hemogram and biochemistry parameters, were recorded. RESULTS The patients with DVT had significantly lower median eosinophil count yet higher median neutrophil to lymphocyte ratio (NLR) than those of control subjects (p<0.001). Similarly, acute DVT patients had lower eosinophil count yet higher NLR values compared to those of indeterminate and chronic DVT patients. However, eosinophil count was not significantly different between chronic DVT and control groups. While NLR ratio was significantly correlated with acute DVT (r=0.34, p<0.001), Spearman's correlation test revealed that eosinophil count was inversely correlated with the presence of acute DVT (r=-0.52, p<0.001). CONCLUSIONS Low eosinophil count may lead the physician to a higher probability of acute DVT rather than indeterminate and chronic DVT.