Inhibifdores pyrrolidine derivatives as factor Xa.

The present invention provides compounds of formula ** **, wherein R1 represents hydrogen, -C1-6alkyl, C3-6 -alkenyl, - (C2-3 alkyl) NRbRc, - (C2-3 alkyl) NHCORb, phenyl or an aromatic heterocyclic group of 5 or 6 members, wherein the phenyl or aromatic heterocyclic group 5 or 6 membered optionally substituted with halogen, or R 1 represents a group XW wherein X represents -C 1-3 alkyl- and W represents -CN, -CO2H, -CONRbRc, -COC 1-6 alkyl, - C1-6 CO2alkyl, phenyl or an aromatic or non-aromatic heterocyclic group of 5 or 6 members containing at least one heteroatom selected from O, N or S, phenyl or aromatic heterocyclic group being optionally substituted with one or more substituents selected from C1-3 -alkyl, C1-3 -alkoxy, - (C1-3 alkyl) OH, halogen, -CN, -CF3, -NH2, -CO2H and -OH; R2 and R3 independently represent hydrogen, C 1-3 alkyl or -CF3 with the proviso that one of R2 and R3 is - CF3 or C1-3 alkyl and the other is hydrogen; Rb and Rc independently represent hydrogen or C1-3 alkyl.