Immunoselected STRO-3 + mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis

Anwar Abdalmula,Laura M. Dooley,Claire Kaufman,Elizabeth A. Washington,Jacqueline V. House,Barbara Blacklaws,Peter Ghosh,Silviu Itescu,S. R. Bailey,Wayne G. Kimpton

Immunoselected STRO-3 + mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis

2017

Anwar Abdalmula
Laura M. Dooley
Claire Kaufman
Elizabeth A. Washington
Jacqueline V. House
Barbara Blacklaws
Peter Ghosh
Silviu Itescu
S. R. Bailey
Wayne G. Kimpton

Background The purpose of this study was to investigate the therapeutic efficacy of intravenously administered immunoselected STRO-3 + mesenchymal precursor cells (MPCs) on clinical scores, joint pathology and cytokine production in an ovine model of monoarthritis.

Keywords:

Interleukin 10
Inflammation
Stem cell
Precursor cell
Immunology
Cytokine
Mesenchymal stem cell
Monoarthritis
Interleukin 17
Medicine
Arthropathy
Arthritis
Joint pain
Synovial fluid
Pathology
Rheumatoid arthritis

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