Design, Synthesis, and Three‐Dimensional Structural Characterization of a Constrained ω‐Loop Excised from Interleukin‐1α.
1993
Abstract The cyclic peptide 1 , containing a 2,7-disubstituted naphthalene spacer, was designed to mimic an exposed Ω-loop present in interleukin-1α, an important mediator of immune and inflammatory responses. The synthesis of this cyclic peptide was accomplished via solution phase fragment condensation methodology. The three dimensional characterization using 2D-NMR techniques revealed it to be an excellent mimic for the Ω-loop sequence 41–48 in interleukin -1α.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
1
References
0
Citations
NaN
KQI