Asymmetric RNA duplexes mediate RNA interference in mammalian cells
2008
Gene silencing by siRNA generally relies on short RNA duplexes containing two strands of the same length. Sun et al. show that an asymmetric duplex with a shortened passenger strand silences its target gene effectively while reducing off-target effects mediated by this strand.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
29
References
109
Citations
NaN
KQI