MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors

Daniela Schwarzenbacher,Christiane Klec,Barbara Pasculli,Stefanie Cerk,Beate Rinner,Michael Karbiener,Cristina Ivan,Raffaela Barbano,Hui Ling,Annika Wulf-Goldenberg,Stefanie Stanzer,Gabriel Rinnerthaler,Herbert Stoeger,Thomas Bauernhofer,Johannes Haybaeck,Gerald Hoefler,Stephan Jahn,Paola Parrella,George A. Calin,Martin Pichler

MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors

2019

Background Non-coding RNAs and especially microRNAs have been discovered to act as master regulators of cancer initiation and progression. The aim of our study was to discover and characterize the function of yet functionally uncharacterized microRNAs in human breast carcinogenesis.

Keywords:

Breast cancer
Cancer research
Cancer
Carcinogenesis
Non-coding RNA
Triple-negative breast cancer
Phosphoinositide 3-kinase
microRNA
Medicine
Cell growth
Stem cell
Transcriptome

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