Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors.

G. S. Falchook,Xiaofei Zhou,Karthik Venkatakrishnan,Razelle Kurzrock,Devalingam Mahalingam,Jonathan W. Goldman,JungAh A. Jung,Claudio Dansky Ullmann,Catherine Milch,Lee S. Rosen,John Sarantopoulos

Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors.

2016

G. S. Falchook
Xiaofei Zhou
Karthik Venkatakrishnan
Razelle Kurzrock
Devalingam Mahalingam
Jonathan W. Goldman
JungAh A. Jung
Claudio Dansky Ullmann
Catherine Milch
Lee S. Rosen
John Sarantopoulos

Objective This study was conducted to characterize the effects of food on single-dose pharmacokinetics (PK) of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in patients with advanced solid tumors.

Keywords:

Alisertib
Advanced Solid Tumor
Aurora Kinase A
Pharmacology
Medicine
Aurora A kinase
Maximum tolerated dose
Lapatinib
Pharmacokinetics
Dasatinib
pharmacology toxicology
in patient

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